Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?
Identifieur interne : 000180 ( Main/Exploration ); précédent : 000179; suivant : 000181Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?
Auteurs : Paul Macdaragh Ryan [Irlande (pays)] ; Noel M. Caplice [Irlande (pays)]Source :
- Obesity (Silver Spring, Md.) [ 1930-739X ] ; 2020.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Betacoronavirus (immunologie), Cytokines (métabolisme), Humains (MeSH), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Obésité (immunologie), Obésité (virologie), Pandémies (MeSH), Pneumopathie virale (immunologie), Pneumopathie virale (virologie), Tissu adipeux (virologie).
- MESH :
- immunologie : Activation des lymphocytes, Betacoronavirus, Infections à coronavirus, Obésité, Pneumopathie virale.
- métabolisme : Cytokines.
- virologie : Infections à coronavirus, Obésité, Pneumopathie virale, Tissu adipeux.
- Humains, Pandémies.
English descriptors
- KwdEn :
- Adipose Tissue (virology), Betacoronavirus (immunology), Coronavirus Infections (immunology), Coronavirus Infections (virology), Cytokines (metabolism), Humans (MeSH), Lymphocyte Activation (immunology), Obesity (immunology), Obesity (virology), Pandemics (MeSH), Pneumonia, Viral (immunology), Pneumonia, Viral (virology).
- MESH :
- chemical , metabolism : Cytokines.
- immunology : Betacoronavirus, Coronavirus Infections, Lymphocyte Activation, Obesity, Pneumonia, Viral.
- virology : Adipose Tissue, Coronavirus Infections, Obesity, Pneumonia, Viral.
- Humans, Pandemics.
Abstract
Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date. Emerging predictors for poor outcomes include advanced age, male sex, preexisting cardiovascular disease, and risk factors including hypertension, diabetes, and, more recently, obesity. This article posits new obesity-driven predictors of poor COVID-19 outcomes, over and above the more obvious extant risks associated with obesity, including cardiometabolic disease and hypoventilation syndrome in intensive care patients. This article also outlines a theoretical mechanistic framework whereby adipose tissue in individuals with obesity may act as a reservoir for more extensive viral spread, with increased shedding, immune activation, and cytokine amplification. This paper proposes studies to test this reservoir concept with a focus on specific cytokine pathways that might be amplified in individuals with obesity and COVID-19. Finally, this paper underscores emerging therapeutic strategies that might benefit subsets of patients in which cytokine amplification is excessive and potentially fatal.
DOI: 10.1002/oby.22843
PubMed: 32314868
PubMed Central: PMC7264526
Affiliations:
Links toward previous steps (curation, corpus...)
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Caplice</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Research in Vascular Biology, APC Microbiome Ireland, University College Cork, Cork University Hospital, Cork, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Centre for Research in Vascular Biology, APC Microbiome Ireland, University College Cork, Cork University Hospital, Cork</wicri:regionArea><wicri:noRegion>Cork</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32314868</idno><idno type="pmid">32314868</idno><idno type="doi">10.1002/oby.22843</idno><idno type="pmc">PMC7264526</idno><idno type="wicri:Area/Main/Corpus">000345</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000345</idno><idno type="wicri:Area/Main/Curation">000345</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000345</idno><idno type="wicri:Area/Main/Exploration">000345</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?</title><author><name sortKey="Ryan, Paul Macdaragh" sort="Ryan, Paul Macdaragh" uniqKey="Ryan P" first="Paul Macdaragh" last="Ryan">Paul Macdaragh Ryan</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Research in Vascular Biology, APC Microbiome Ireland, University College Cork, Cork University Hospital, Cork, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Centre for Research in Vascular Biology, APC Microbiome Ireland, University College Cork, Cork University Hospital, Cork</wicri:regionArea><wicri:noRegion>Cork</wicri:noRegion></affiliation></author><author><name sortKey="Caplice, Noel M" sort="Caplice, Noel M" uniqKey="Caplice N" first="Noel M" last="Caplice">Noel M. Caplice</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Research in Vascular Biology, APC Microbiome Ireland, University College Cork, Cork University Hospital, Cork, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Centre for Research in Vascular Biology, APC Microbiome Ireland, University College Cork, Cork University Hospital, Cork</wicri:regionArea><wicri:noRegion>Cork</wicri:noRegion></affiliation></author></analytic><series><title level="j">Obesity (Silver Spring, Md.)</title><idno type="eISSN">1930-739X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipose Tissue (virology)</term><term>Betacoronavirus (immunology)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Cytokines (metabolism)</term><term>Humans (MeSH)</term><term>Lymphocyte Activation (immunology)</term><term>Obesity (immunology)</term><term>Obesity (virology)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (immunology)</term><term>Pneumonia, Viral (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term><term>Betacoronavirus (immunologie)</term><term>Cytokines (métabolisme)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Obésité (immunologie)</term><term>Obésité (virologie)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (immunologie)</term><term>Pneumopathie virale (virologie)</term><term>Tissu adipeux (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term><term>Betacoronavirus</term><term>Infections à coronavirus</term><term>Obésité</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Betacoronavirus</term><term>Coronavirus Infections</term><term>Lymphocyte Activation</term><term>Obesity</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Obésité</term><term>Pneumopathie virale</term><term>Tissu adipeux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Adipose Tissue</term><term>Coronavirus Infections</term><term>Obesity</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Pandémies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date. Emerging predictors for poor outcomes include advanced age, male sex, preexisting cardiovascular disease, and risk factors including hypertension, diabetes, and, more recently, obesity. This article posits new obesity-driven predictors of poor COVID-19 outcomes, over and above the more obvious extant risks associated with obesity, including cardiometabolic disease and hypoventilation syndrome in intensive care patients. This article also outlines a theoretical mechanistic framework whereby adipose tissue in individuals with obesity may act as a reservoir for more extensive viral spread, with increased shedding, immune activation, and cytokine amplification. This paper proposes studies to test this reservoir concept with a focus on specific cytokine pathways that might be amplified in individuals with obesity and COVID-19. Finally, this paper underscores emerging therapeutic strategies that might benefit subsets of patients in which cytokine amplification is excessive and potentially fatal.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32314868</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>06</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1930-739X</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>07</Month></PubDate></JournalIssue><Title>Obesity (Silver Spring, Md.)</Title><ISOAbbreviation>Obesity (Silver Spring)</ISOAbbreviation></Journal><ArticleTitle>Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?</ArticleTitle><Pagination><MedlinePgn>1191-1194</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/oby.22843</ELocationID><Abstract><AbstractText>Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date. Emerging predictors for poor outcomes include advanced age, male sex, preexisting cardiovascular disease, and risk factors including hypertension, diabetes, and, more recently, obesity. This article posits new obesity-driven predictors of poor COVID-19 outcomes, over and above the more obvious extant risks associated with obesity, including cardiometabolic disease and hypoventilation syndrome in intensive care patients. This article also outlines a theoretical mechanistic framework whereby adipose tissue in individuals with obesity may act as a reservoir for more extensive viral spread, with increased shedding, immune activation, and cytokine amplification. This paper proposes studies to test this reservoir concept with a focus on specific cytokine pathways that might be amplified in individuals with obesity and COVID-19. 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Accessed April 6, 2020. http://www.chictr.org.cn/showprojen.aspx?proj=49409</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Irlande (pays)</li></country></list><tree><country name="Irlande (pays)"><noRegion><name sortKey="Ryan, Paul Macdaragh" sort="Ryan, Paul Macdaragh" uniqKey="Ryan P" first="Paul Macdaragh" last="Ryan">Paul Macdaragh Ryan</name></noRegion><name sortKey="Caplice, Noel M" sort="Caplice, Noel M" uniqKey="Caplice N" first="Noel M" last="Caplice">Noel M. Caplice</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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